By Train:

Santa Maria Novella (Walking Distance)

By Plane:

Peretola International Airport (9.5 Km)
Galileo Galilei International Airport - Pisa (83 Km)

By Car:

You may take Motorway A1 "Autostrada Del Sole" which connects Florence both with Southern and Northern Italy. Take the exit "Firenze Sud" if coming from Rome or take the exit "Firenze Nord" if coming from Milan, Bologna or Venice.